Research ArticleCancer

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

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Science Translational Medicine  12 Feb 2020:
Vol. 12, Issue 530, eaax6337
DOI: 10.1126/scitranslmed.aax6337

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Spinning ancient peptides into gold

Tumors co-opt macrophages to promote tumor growth and evasion from immune surveillance. Through biophysical homology screening, Jaynes et al. identified an evolutionarily conserved motif across host defense peptides and innate defense regulators. On the basis of this motif, the authors synthesized a 10-mer peptide, RP-182, which reprograms tumor-associated macrophages and increases cancer cell phagocytosis and antitumor immune responses in murine cancer models. In models of pancreatic ductal adenocarcinoma, RP-182 improved responses to chemotherapy and checkpoint blockade. These results show that targeting subsets of tumor-associated macrophages could improve treatment for solid organ cancers and that evolutionarily conserved innate defense regulators can provide leads for potential cancer treatments.

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