Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri; Ioana Lia; Rosa Vincent; Courtney Coker; Samuel Castro; Piper M. Treuting; Taylor E. Hinchliffe; Nicholas Arpaia; Tal Danino

doi:10.1126/scitranslmed.aax0876

Research ArticleCancer

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri ¹,
Ioana Lia¹,
Rosa Vincent¹,
Courtney Coker¹,
Samuel Castro¹,
Piper M. Treuting²,
Taylor E. Hinchliffe¹,
Nicholas Arpaia³,⁴ and
Tal Danino ¹,⁴,⁵,*

¹Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
²Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
³Department of Microbiology & Immunology, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
⁴Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.
⁵Data Science Institute, Columbia University, New York, NY 10027, USA.

↵*Corresponding author. Email: td2506{at}columbia.edu

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Science Translational Medicine 12 Feb 2020:
Vol. 12, Issue 530, eaax0876
DOI: 10.1126/scitranslmed.aax0876

Candice R. Gurbatri

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Ioana Lia

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Rosa Vincent

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Courtney Coker

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Samuel Castro

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Piper M. Treuting

Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.

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Taylor E. Hinchliffe

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

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Nicholas Arpaia

Department of Microbiology & Immunology, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.

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Tal Danino

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.

Data Science Institute, Columbia University, New York, NY 10027, USA.

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For correspondence: td2506@columbia.edu

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Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

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