Research ArticleRegenerative Medicine
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration
- View ORCID ProfileCourtney Ackeifi1,*,
- Peng Wang1,*,
- Esra Karakose1,*,
- Jocelyn E. Manning Fox2,
- View ORCID ProfileBryan J. González3,
- Hongtao Liu1,
- View ORCID ProfileJessica Wilson1,
- Ethan Swartz1,
- Cecilia Berrouet1,
- Yansui Li1,
- Kunal Kumar4,
- View ORCID ProfilePatrick E. MacDonald2,
- Roberto Sanchez4,
- Bernard Thorens5,
- View ORCID ProfileRobert DeVita4,
- View ORCID ProfileDirk Homann1,
- Dieter Egli3,
- View ORCID ProfileDonald K. Scott1,
- View ORCID ProfileAdolfo Garcia-Ocaña1 and
- View ORCID ProfileAndrew F. Stewart1,†
- 1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 2Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
- 3Naomi Berrie Diabetes Center and Columbia Stem Cell Center, Columbia University, New York, NY 10032, USA.
- 4Department of Pharmacological Sciences, and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 5Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland.
- ↵†Corresponding author. Email: andrew.stewart{at}mssm.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 12 Feb 2020:
Vol. 12, Issue 530, eaaw9996
DOI: 10.1126/scitranslmed.aaw9996
Vol. 12, Issue 530, eaaw9996
DOI: 10.1126/scitranslmed.aaw9996
Courtney Ackeifi
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Peng Wang
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Esra Karakose
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jocelyn E. Manning Fox
2Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Bryan J. González
3Naomi Berrie Diabetes Center and Columbia Stem Cell Center, Columbia University, New York, NY 10032, USA.
Hongtao Liu
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jessica Wilson
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ethan Swartz
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cecilia Berrouet
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yansui Li
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kunal Kumar
4Department of Pharmacological Sciences, and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Patrick E. MacDonald
2Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Roberto Sanchez
4Department of Pharmacological Sciences, and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bernard Thorens
5Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland.
Robert DeVita
4Department of Pharmacological Sciences, and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dirk Homann
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dieter Egli
3Naomi Berrie Diabetes Center and Columbia Stem Cell Center, Columbia University, New York, NY 10032, USA.
Donald K. Scott
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adolfo Garcia-Ocaña
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Andrew F. Stewart
1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
