Research ArticleRegenerative Medicine

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

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Science Translational Medicine  12 Feb 2020:
Vol. 12, Issue 530, eaaw9996
DOI: 10.1126/scitranslmed.aaw9996

Article Information

vol. 12 no. 530

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 15, 2019
  • Resubmitted August 7, 2019
  • Accepted for publication January 9, 2020
  • .

Author Information

  1. Courtney Ackeifi1,*,
  2. Peng Wang1,*,
  3. Esra Karakose1,*,
  4. Jocelyn E. Manning Fox2,
  5. Bryan J. González3,
  6. Hongtao Liu1,
  7. Jessica Wilson1,
  8. Ethan Swartz1,
  9. Cecilia Berrouet1,
  10. Yansui Li1,
  11. Kunal Kumar4,
  12. Patrick E. MacDonald2,
  13. Roberto Sanchez4,
  14. Bernard Thorens5,
  15. Robert DeVita4,
  16. Dirk Homann1,
  17. Dieter Egli3,
  18. Donald K. Scott1,
  19. Adolfo Garcia-Ocaña1 and
  20. Andrew F. Stewart1,
  1. 1Diabetes, Obesity and Metabolism Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  2. 2Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  3. 3Naomi Berrie Diabetes Center and Columbia Stem Cell Center, Columbia University, New York, NY 10032, USA.
  4. 4Department of Pharmacological Sciences, and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  5. 5Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland.
  1. Corresponding author. Email: andrew.stewart{at}mssm.edu
  • * These authors contributed equally to this work.

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