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Research ArticleNEURODEGENERATIVE DISEASES
APOE genotype regulates pathology and disease progression in synucleinopathy
- View ORCID ProfileAlbert A. Davis1,2,*,
- View ORCID ProfileCasey E. Inman1,2,
- Zachary M. Wargel1,2,
- View ORCID ProfileUmber Dube1,3,
- View ORCID ProfileBrittany M. Freeberg1,2,
- View ORCID ProfileAlexander Galluppi1,2,
- Jessica N. Haines1,2,
- Dhruva D. Dhavale1,2,
- View ORCID ProfileRebecca Miller1,2,
- View ORCID ProfileFahim A. Choudhury1,2,
- View ORCID ProfilePatrick M. Sullivan4,
- View ORCID ProfileCarlos Cruchaga1,3,
- Joel S. Perlmutter1,2,5,
- View ORCID ProfileJason D. Ulrich1,2,
- View ORCID ProfileBruno A. Benitez1,3,
- View ORCID ProfilePaul T. Kotzbauer1,2 and
- View ORCID ProfileDavid M. Holtzman1,2,6,*
- 1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
- 2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
- 3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.
- 4Department of Medicine, Duke University Medical Center, Durham VAMC and Geriatric Research Clinical Center, Durham, NC 27705, USA.
- 5Departments of Neuroscience and Radiology, Programs in Physical and Occupational Therapy, Washington University, St. Louis, MO 63110, USA.
- 6Knight Alzheimer’s Disease Research Center, Washington University, St. Louis, MO 63110, USA.
- ↵*Corresponding author. Email: albert.a.davis{at}wustl.edu (A.A.D.); holtzman{at}wustl.edu (D.M.H.)
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Science Translational Medicine 05 Feb 2020:
Vol. 12, Issue 529, eaay3069
DOI: 10.1126/scitranslmed.aay3069
Vol. 12, Issue 529, eaay3069
DOI: 10.1126/scitranslmed.aay3069
Albert A. Davis
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Casey E. Inman
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Zachary M. Wargel
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Umber Dube
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.
Brittany M. Freeberg
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Alexander Galluppi
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Jessica N. Haines
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Dhruva D. Dhavale
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Rebecca Miller
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Fahim A. Choudhury
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Patrick M. Sullivan
4Department of Medicine, Duke University Medical Center, Durham VAMC and Geriatric Research Clinical Center, Durham, NC 27705, USA.
Carlos Cruchaga
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.
Joel S. Perlmutter
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
5Departments of Neuroscience and Radiology, Programs in Physical and Occupational Therapy, Washington University, St. Louis, MO 63110, USA.
Jason D. Ulrich
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Bruno A. Benitez
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.
Paul T. Kotzbauer
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
David M. Holtzman
1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
2Department of Neurology, Washington University, St. Louis, MO 63110, USA.
6Knight Alzheimer’s Disease Research Center, Washington University, St. Louis, MO 63110, USA.
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