APOE genotype regulates pathology and disease progression in synucleinopathy

Albert A. Davis; Casey E. Inman; Zachary M. Wargel; Umber Dube; Brittany M. Freeberg; Alexander Galluppi; Jessica N. Haines; Dhruva D. Dhavale; Rebecca Miller; Fahim A. Choudhury; Patrick M. Sullivan; Carlos Cruchaga; Joel S. Perlmutter; Jason D. Ulrich; Bruno A. Benitez; Paul T. Kotzbauer; David M. Holtzman

doi:10.1126/scitranslmed.aay3069

Research ArticleNEURODEGENERATIVE DISEASES

APOE genotype regulates pathology and disease progression in synucleinopathy

View ORCID ProfileAlbert A. Davis ¹,²,*,
View ORCID ProfileCasey E. Inman¹,²,
Zachary M. Wargel¹,²,
View ORCID ProfileUmber Dube¹,³,
View ORCID ProfileBrittany M. Freeberg¹,²,
View ORCID ProfileAlexander Galluppi¹,²,
Jessica N. Haines¹,²,
Dhruva D. Dhavale¹,²,
View ORCID ProfileRebecca Miller¹,²,
View ORCID ProfileFahim A. Choudhury¹,²,
View ORCID ProfilePatrick M. Sullivan⁴,
View ORCID ProfileCarlos Cruchaga ¹,³,
Joel S. Perlmutter ¹,²,⁵,
View ORCID ProfileJason D. Ulrich¹,²,
View ORCID ProfileBruno A. Benitez¹,³,
View ORCID ProfilePaul T. Kotzbauer ¹,² and
View ORCID ProfileDavid M. Holtzman ¹,²,⁶,*

¹Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.
²Department of Neurology, Washington University, St. Louis, MO 63110, USA.
³Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.
⁴Department of Medicine, Duke University Medical Center, Durham VAMC and Geriatric Research Clinical Center, Durham, NC 27705, USA.
⁵Departments of Neuroscience and Radiology, Programs in Physical and Occupational Therapy, Washington University, St. Louis, MO 63110, USA.
⁶Knight Alzheimer’s Disease Research Center, Washington University, St. Louis, MO 63110, USA.

↵*Corresponding author. Email: albert.a.davis{at}wustl.edu (A.A.D.); holtzman{at}wustl.edu (D.M.H.)

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Science Translational Medicine 05 Feb 2020:
Vol. 12, Issue 529, eaay3069
DOI: 10.1126/scitranslmed.aay3069

Albert A. Davis

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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ORCID record for Albert A. Davis
For correspondence: albert.a.davis@wustl.edu holtzman@wustl.edu

Casey E. Inman

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Zachary M. Wargel

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Umber Dube

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.

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Brittany M. Freeberg

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Alexander Galluppi

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Jessica N. Haines

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Dhruva D. Dhavale

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Rebecca Miller

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Fahim A. Choudhury

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Patrick M. Sullivan

4Department of Medicine, Duke University Medical Center, Durham VAMC and Geriatric Research Clinical Center, Durham, NC 27705, USA.

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ORCID record for Patrick M. Sullivan

Carlos Cruchaga

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.

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Joel S. Perlmutter

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

5Departments of Neuroscience and Radiology, Programs in Physical and Occupational Therapy, Washington University, St. Louis, MO 63110, USA.

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Jason D. Ulrich

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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Bruno A. Benitez

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

3Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.

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Paul T. Kotzbauer

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

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David M. Holtzman

1Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2Department of Neurology, Washington University, St. Louis, MO 63110, USA.

6Knight Alzheimer’s Disease Research Center, Washington University, St. Louis, MO 63110, USA.

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ORCID record for David M. Holtzman
For correspondence: albert.a.davis@wustl.edu holtzman@wustl.edu

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APOE genotype regulates pathology and disease progression in synucleinopathy

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