Research ArticleAsthma

Distinct immune phenotypes in infants developing asthma during childhood

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Science Translational Medicine  05 Feb 2020:
Vol. 12, Issue 529, eaaw0258
DOI: 10.1126/scitranslmed.aaw0258

Infant immunity and asthma

Asthma is traditionally thought of as a type 2 allergic disease, but its presentation and pathogenesis are quite heterogenous. To better understand early immune responses that are associated with asthma, Thysen et al. leveraged samples from a longitudinal cohort of hundreds of children. Blood cells collected at 18 months of age were stimulated in vitro with various ligands, and different immune phenotypes were related to clinical asthma outcomes. The investigators revealed sex differences, an influence of microbial exposure, and immune traits associated with transient or persistent asthma. This systems approach provides valuable information on early life immune profiles and how they relate to asthma development.

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