05 February 2020
Vol 12, Issue 529

About The Cover

Cover image expansion

ONLINE COVER Sex-Linked Differences in Pain Pathways. This image shows colocalization (yellow) of the prolactin receptor (green) with the mu opioid receptor (red) in a dorsal root ganglion from a female mouse. Males and females experience pain differently. To disentangle the mechanisms mediating this difference, Chen et al. studied opioid-induced hyperalgesia (OIH) in male and female mice. In female animals, OIH was mediated by decreased expression of the prolactin receptor isoform L and increased activation of the isoform S. Overexpression of prolactin receptor isoform L or inhibition of circulating prolactin prevented OIH in female mice. Targeting prolactin signaling may be effective for treating OIH in women. [CREDIT: FRANK PORRECA]