Research ArticleTuberculosis

Immune correlates of tuberculosis disease and risk translate across species

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Science Translational Medicine  29 Jan 2020:
Vol. 12, Issue 528, eaay0233
DOI: 10.1126/scitranslmed.aay0233

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Translating TB

Mycobacterium tuberculosis can cause tuberculosis (TB) disease in humans, although the majority of infected individuals naturally control infection and never show symptoms. To better understand immune control of M. tuberculosis, Ahmed et al. compared gene expression data from infected humans and different animal models. Gene expression differing between disease progression and control identified potentially beneficial shared pathways. Some pathways were followed up by examining M. tuberculosis infection in gene-deficient inbred mice. These results highlight how focusing on commonalities in TB infection can lead to new insights for treating TB.

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