Mixed chimerism and acceptance of kidney transplants after immunosuppressive drug withdrawal

Stephan Busque; John D. Scandling; Robert Lowsky; Judith Shizuru; Kent Jensen; Jeffrey Waters; Hsin-Hsu Wu; Kevin Sheehan; Asha Shori; Okmi Choi; Thomas Pham; Marcelo A. Fernandez Vina; Richard Hoppe; John Tamaresis; Philip Lavori; Edgar G. Engleman; Everett Meyer; Samuel Strober

doi:10.1126/scitranslmed.aax8863

Research ArticleTRANSPLANT

Mixed chimerism and acceptance of kidney transplants after immunosuppressive drug withdrawal

View ORCID ProfileStephan Busque¹,
John D. Scandling²,
View ORCID ProfileRobert Lowsky³,
View ORCID ProfileJudith Shizuru³,
View ORCID ProfileKent Jensen⁴,
Jeffrey Waters⁴,
View ORCID ProfileHsin-Hsu Wu³,⁴,
View ORCID ProfileKevin Sheehan⁴,
View ORCID ProfileAsha Shori¹,
View ORCID ProfileOkmi Choi⁵,
View ORCID ProfileThomas Pham¹,
View ORCID ProfileMarcelo A. Fernandez Vina⁵,
View ORCID ProfileRichard Hoppe⁶,
John Tamaresis⁷,
Philip Lavori⁷,
View ORCID ProfileEdgar G. Engleman⁵,
View ORCID ProfileEverett Meyer³ and
View ORCID ProfileSamuel Strober ⁴,*

¹Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
²Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
³Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁴Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁵Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁶Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA.

↵*Corresponding author. Email: sstrober{at}stanford.edu

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Science Translational Medicine 29 Jan 2020:
Vol. 12, Issue 528, eaax8863
DOI: 10.1126/scitranslmed.aax8863

Stephan Busque

1Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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ORCID record for Stephan Busque

John D. Scandling

2Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Robert Lowsky

3Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Judith Shizuru

3Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Kent Jensen

4Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Jeffrey Waters

4Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Hsin-Hsu Wu

3Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

4Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Kevin Sheehan

4Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Asha Shori

1Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Okmi Choi

5Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Thomas Pham

1Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Marcelo A. Fernandez Vina

5Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Richard Hoppe

6Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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John Tamaresis

7Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Philip Lavori

7Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Edgar G. Engleman

5Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Everett Meyer

3Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Samuel Strober

4Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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For correspondence: sstrober@stanford.edu

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Mixed chimerism and acceptance of kidney transplants after immunosuppressive drug withdrawal

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