Research ArticleMetabolic Disease

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

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Science Translational Medicine  29 Jan 2020:
Vol. 12, Issue 528, eaau5956
DOI: 10.1126/scitranslmed.aau5956

Article Information

vol. 12 no. 528

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 14, 2018
  • Resubmitted July 23, 2019
  • Accepted for publication December 30, 2019
  • .

Author Information

  1. Geetanjali Sharma1,
  2. Chelin Hu2,
  3. Daniela I. Staquicini3,4,
  4. Jonathan L. Brigman5,
  5. Meilian Liu6,7,
  6. Franck Mauvais-Jarvis8,9,
  7. Renata Pasqualini3,4,
  8. Wadih Arap4,10,
  9. Jeffrey B. Arterburn11,
  10. Helen J. Hathaway2,12 and
  11. Eric R. Prossnitz1,7,12,*
  1. 1Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  2. 2Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  3. 3Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
  4. 4Rutgers Cancer Institute of New Jersey, Newark, NJ 07103, USA.
  5. 5Department of Neurosciences, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  6. 6Department of Biochemistry and Molecular Biology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  7. 7Center of Biomedical Research Excellence in Autophagy, Inflammation and Metabolism, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  8. 8Diabetes Discovery and Sex-Based Medicine Laboratory, Section of Endocrinology and Metabolism, Department of Medicine, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
  9. 9Section of Endocrinology, Southeast Louisiana Veterans Administration Health Care System, New Orleans, LA 70112, USA.
  10. 10Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
  11. 11Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM, 88003, USA.
  12. 12University of New Mexico Comprehensive Cancer Center, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  1. *Corresponding author. Email: eprossnitz{at}salud.unm.edu

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