29 January 2020
Vol 12, Issue 528

About The Cover

Cover image expansion

ONLINE COVER Taming Triglycerides. Elevated plasma lipids are associated with risk of cardiovascular disease. This image shows a snapshot of the simulated interaction between a peptide with therapeutic potential (D6PV, blue and red ribbon structures) and a trilayer of triglyceride-rich lipids. Wolska et al. developed D6PV to reduce triglycerides. By mimicking apolipoprotein C-II and antagonizing apolipoprotein C-III, D6PV induced lipolysis in plasma from patients with hypertriglyceridemia ex vivo. This dual-function lipid-lowering peptide also reduced low-density lipoproteins, triglycerides, and apolipoprotein C-III in mouse models, suggesting it could help to treat hypertriglyceridemia. [CREDIT: WOLSKA ET AL./SCIENCE TRANSLATIONAL MEDICINE]