Contents

29 January 2020
Vol 12, Issue 528

About The Cover

Cover image expansion

ONLINE COVER Taming Triglycerides. Elevated plasma lipids are associated with risk of cardiovascular disease. This image shows a snapshot of the simulated interaction between a peptide with therapeutic potential (D6PV, blue and red ribbon structures) and a trilayer of triglyceride-rich lipids. Wolska et al. developed D6PV to reduce triglycerides. By mimicking apolipoprotein C-II and antagonizing apolipoprotein C-III, D6PV induced lipolysis in plasma from patients with hypertriglyceridemia ex vivo. This dual-function lipid-lowering peptide also reduced low-density lipoproteins, triglycerides, and apolipoprotein C-III in mouse models, suggesting it could help to treat hypertriglyceridemia. [CREDIT: WOLSKA ET AL./SCIENCE TRANSLATIONAL MEDICINE]