Research ArticleCancer

PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma

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Science Translational Medicine  22 Jan 2020:
Vol. 12, Issue 527, eaax3772
DOI: 10.1126/scitranslmed.aax3772

The secrets of malignant secretion

Cancer cells produce and secrete a variety of proteins that promote tumorigenesis, in a process known as malignant secretion. Tan et al. identified a region of chromosome 1 that is often amplified in cancer and plays a key role in malignant secretion. In particular, the authors discovered a mechanism by which a Golgi-associated enzyme called PI4KIIIβ promotes secretion of proteins involved in lung cancer survival and metastasis. The authors identified and optimized chemical inhibitors of PI4KIIIβ and then tested their effectiveness at blocking malignant secretion and reducing cancer cells’ invasiveness in vitro and in multiple mouse models of cancer.

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