The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas

Ricardo Gargini; Berta Segura-Collar; Beatriz Herránz; Vega García-Escudero; Andrés Romero-Bravo; Felipe J. Núñez; Daniel García-Pérez; Jacqueline Gutiérrez-Guamán; Angel Ayuso-Sacido; Joan Seoane; Angel Pérez-Núñez; Juan M. Sepúlveda-Sánchez; Aurelio Hernández-Laín; María G. Castro; Ramón García-Escudero; Jesús Ávila; Pilar Sánchez-Gómez

doi:10.1126/scitranslmed.aax1501

Research ArticleCancer

The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas

View ORCID ProfileRicardo Gargini¹,²,*,
View ORCID ProfileBerta Segura-Collar²,*,
View ORCID ProfileBeatriz Herránz²,³,
View ORCID ProfileVega García-Escudero¹,⁴,
View ORCID ProfileAndrés Romero-Bravo²,
View ORCID ProfileFelipe J. Núñez⁵,
View ORCID ProfileDaniel García-Pérez⁶,
View ORCID ProfileJacqueline Gutiérrez-Guamán⁷,
Angel Ayuso-Sacido ⁸,⁹,¹⁰,
Joan Seoane ¹¹,¹²,¹³,
View ORCID ProfileAngel Pérez-Núñez⁶,
Juan M. Sepúlveda-Sánchez ⁷,
View ORCID ProfileAurelio Hernández-Laín ⁷,
View ORCID ProfileMaría G. Castro ⁵,
View ORCID ProfileRamón García-Escudero ⁷,¹²,¹⁴,
View ORCID ProfileJesús Ávila ¹,¹⁵,† and
View ORCID ProfilePilar Sánchez-Gómez ²,†

¹Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Madrid 28049, Spain.
²Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid 28220, Spain.
³Facultad de Medicina de la Universidad Francisco de Vitoria, Madrid 28223, Spain.
⁴Dto. de Anatomía, Histología y Neurociencia, Facultad de Medicina de la Universidad Autónoma, Madrid 28029, Spain.
⁵Department of Neurosurgery/Department of Cell & Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
⁶Dto. Neurocirugía, Hospital 12 de Octubre, Univ. Complutense, Madrid 28041, Spain.
⁷Instituto de Investigaciones Biomédicas I+12, Hosp. 12 de Octubre, Madrid 28041, Spain.
⁸Fundación de Investigación HM Hospitales, HM Hospitales, Madrid 28015, Spain.
⁹Facultad de Medicina (IMMA), Universidad San Pablo-CEU, Madrid 28925, Spain.
¹⁰IMDEA Nanoscience, Madrid 28049, Spain.
¹¹Vall d'Hebron Institute of Oncology (VHIO), Barcelona 08035, Spain.
¹²Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid 28029, Spain.
¹³Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.
¹⁴Unidad de Oncología Molecular, CIEMAT, Madrid 28040, Spain.
¹⁵Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid 28029, Spain.

↵†Corresponding author. Email: psanchez{at}isciii.es (P.S.-G.); jesus.avila{at}csic.es (J.A.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 22 Jan 2020:
Vol. 12, Issue 527, eaax1501
DOI: 10.1126/scitranslmed.aax1501

Ricardo Gargini

1Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Madrid 28049, Spain.

2Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid 28220, Spain.

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ORCID record for Ricardo Gargini

Berta Segura-Collar

2Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid 28220, Spain.

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ORCID record for Berta Segura-Collar

Beatriz Herránz

2Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid 28220, Spain.

3Facultad de Medicina de la Universidad Francisco de Vitoria, Madrid 28223, Spain.

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Vega García-Escudero

1Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Madrid 28049, Spain.

4Dto. de Anatomía, Histología y Neurociencia, Facultad de Medicina de la Universidad Autónoma, Madrid 28029, Spain.

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Andrés Romero-Bravo

2Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid 28220, Spain.

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Felipe J. Núñez

5Department of Neurosurgery/Department of Cell & Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

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Daniel García-Pérez

6Dto. Neurocirugía, Hospital 12 de Octubre, Univ. Complutense, Madrid 28041, Spain.

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Jacqueline Gutiérrez-Guamán

7Instituto de Investigaciones Biomédicas I+12, Hosp. 12 de Octubre, Madrid 28041, Spain.

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Angel Ayuso-Sacido

8Fundación de Investigación HM Hospitales, HM Hospitales, Madrid 28015, Spain.

9Facultad de Medicina (IMMA), Universidad San Pablo-CEU, Madrid 28925, Spain.

10IMDEA Nanoscience, Madrid 28049, Spain.

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Joan Seoane

11Vall d'Hebron Institute of Oncology (VHIO), Barcelona 08035, Spain.

12Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid 28029, Spain.

13Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.

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Angel Pérez-Núñez

6Dto. Neurocirugía, Hospital 12 de Octubre, Univ. Complutense, Madrid 28041, Spain.

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Juan M. Sepúlveda-Sánchez

7Instituto de Investigaciones Biomédicas I+12, Hosp. 12 de Octubre, Madrid 28041, Spain.

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Aurelio Hernández-Laín

7Instituto de Investigaciones Biomédicas I+12, Hosp. 12 de Octubre, Madrid 28041, Spain.

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María G. Castro

5Department of Neurosurgery/Department of Cell & Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

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Ramón García-Escudero

7Instituto de Investigaciones Biomédicas I+12, Hosp. 12 de Octubre, Madrid 28041, Spain.

12Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid 28029, Spain.

14Unidad de Oncología Molecular, CIEMAT, Madrid 28040, Spain.

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Jesús Ávila

1Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Madrid 28049, Spain.

15Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid 28029, Spain.

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For correspondence: psanchez@isciii.es jesus.avila@csic.es

Pilar Sánchez-Gómez

2Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid 28220, Spain.

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ORCID record for Pilar Sánchez-Gómez
For correspondence: psanchez@isciii.es jesus.avila@csic.es

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The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas

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