22 January 2020
Vol 12, Issue 527

About The Cover

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ONLINE COVER Mosquito-Fighting Macrophages. Many human diseases are transmitted by mosquito bites. Bryden et al. tested different methods of innate immune activation in mosquito-bitten mouse skin. They discovered that TLR7 stimulation (ball and stick structures) induced an interferon type I response in skin macrophages, which restricted arbovirus replication and dissemination (multicolored spheres). A TLR7 agonist cream was therapeutic in mice infected with alphavirus and in human skin explant models of flavivirus infection. These findings could pave the way for a topical intervention that acts broadly against mosquito-transmitted viral diseases. [CREDIT: STEVEN BRYDEN]