Research ArticleAlzheimer’s Disease

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

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Science Translational Medicine  15 Jan 2020:
Vol. 12, Issue 526, eaay6931
DOI: 10.1126/scitranslmed.aay6931

Article Information

vol. 12 no. 526

PubMed: 
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History: 
  • Received for publication July 10, 2019
  • Accepted for publication November 14, 2019
  • .

Author Information

  1. Fang Zhang1,*,
  2. Mary Gannon1,*,
  3. Yunjia Chen1,
  4. Shun Yan2,
  5. Sixue Zhang3,
  6. Wendy Feng1,
  7. Jiahui Tao1,
  8. Bingdong Sha1,
  9. Zhenghui Liu4,
  10. Takashi Saito5,,
  11. Takaomi Saido5,
  12. C. Dirk Keene6,
  13. Kai Jiao2,
  14. Erik D. Roberson7,
  15. Huaxi Xu8 and
  16. Qin Wang1,
  1. 1Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  2. 2Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  3. 3Department of Chemistry, Southern Research Institute, Birmingham, AL 35205, USA.
  4. 4Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  5. 5Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198, Japan.
  6. 6Department of Pathology, University of Washington, Seattle, WA 98104, USA.
  7. 7Alzheimer’s Disease Center, Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  8. 8Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  1. Corresponding author. Email: qinwang{at}uab.edu
  • * These authors contributed equally to this work.

  • Present address: Department of Neurocognitive Science, Nagoya City University Graduate School of Medical Science, Aichi 467-8601, Japan.

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