Research ArticleESSENTIAL TREMOR
Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology
- View ORCID ProfileMing-Kai Pan1,2,3,4,5,*,
- View ORCID ProfileYong-Shi Li6,
- Shi-Bing Wong6,7,
- View ORCID ProfileChun-Lun Ni6,
- Yi-Mei Wang5,
- Wen-Chuan Liu1,2,
- View ORCID ProfileLiang-Yin Lu3,
- Jye-Chang Lee4,
- View ORCID ProfileEtty P. Cortes8,
- Jean-Paul G. Vonsattel8,
- View ORCID ProfileQian Sun9,10,
- View ORCID ProfileElan D. Louis11,12,
- Phyllis L. Faust8 and
- View ORCID ProfileSheng-Han Kuo6,13,*
- 1Department of Medical Research, National Taiwan University Hospital, Taipei City 10002, Taiwan.
- 2Institute of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei City 10051, Taiwan.
- 3Neurobiology and Cognitive Science Center, National Taiwan University, Taipei City 10051, Taiwan.
- 4Molecular Imaging Center, National Taiwan University, Taipei City 10051, Taiwan.
- 5Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.
- 6Department of Neurology, Columbia University, New York, NY 10032, USA.
- 7Department of Pediatrics, Taipei Tzu Chi Hospital, Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
- 8Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
- 9Department of Neuroscience, Columbia University, New York, NY 10032, USA.
- 10Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44016, USA.
- 11Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06519, USA.
- 12Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.
- 13Initiative of Columbia Ataxia and Tremor, New York, NY 10032, USA.
- ↵*Corresponding author. Email: emorymkpan{at}ntu.edu.tw (M.-K.P.); sk3295{at}columbia.edu (S.-H.K.)
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Science Translational Medicine 15 Jan 2020:
Vol. 12, Issue 526, eaay1769
DOI: 10.1126/scitranslmed.aay1769
Vol. 12, Issue 526, eaay1769
DOI: 10.1126/scitranslmed.aay1769
Ming-Kai Pan
1Department of Medical Research, National Taiwan University Hospital, Taipei City 10002, Taiwan.
2Institute of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei City 10051, Taiwan.
3Neurobiology and Cognitive Science Center, National Taiwan University, Taipei City 10051, Taiwan.
4Molecular Imaging Center, National Taiwan University, Taipei City 10051, Taiwan.
5Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.
Yong-Shi Li
6Department of Neurology, Columbia University, New York, NY 10032, USA.
Shi-Bing Wong
6Department of Neurology, Columbia University, New York, NY 10032, USA.
7Department of Pediatrics, Taipei Tzu Chi Hospital, Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Chun-Lun Ni
6Department of Neurology, Columbia University, New York, NY 10032, USA.
Yi-Mei Wang
5Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.
Wen-Chuan Liu
1Department of Medical Research, National Taiwan University Hospital, Taipei City 10002, Taiwan.
2Institute of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei City 10051, Taiwan.
Liang-Yin Lu
3Neurobiology and Cognitive Science Center, National Taiwan University, Taipei City 10051, Taiwan.
Jye-Chang Lee
4Molecular Imaging Center, National Taiwan University, Taipei City 10051, Taiwan.
Etty P. Cortes
8Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Jean-Paul G. Vonsattel
8Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Qian Sun
9Department of Neuroscience, Columbia University, New York, NY 10032, USA.
10Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44016, USA.
Elan D. Louis
11Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06519, USA.
12Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.
Phyllis L. Faust
8Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Sheng-Han Kuo
6Department of Neurology, Columbia University, New York, NY 10032, USA.
13Initiative of Columbia Ataxia and Tremor, New York, NY 10032, USA.
