Research ArticleESSENTIAL TREMOR

Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology

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Science Translational Medicine  15 Jan 2020:
Vol. 12, Issue 526, eaay1769
DOI: 10.1126/scitranslmed.aay1769

Article Information

vol. 12 no. 526

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 27, 2019
  • Accepted for publication November 15, 2019
  • .

Author Information

  1. Ming-Kai Pan1,2,3,4,5,*,
  2. Yong-Shi Li6,
  3. Shi-Bing Wong6,7,
  4. Chun-Lun Ni6,
  5. Yi-Mei Wang5,
  6. Wen-Chuan Liu1,2,
  7. Liang-Yin Lu3,
  8. Jye-Chang Lee4,
  9. Etty P. Cortes8,
  10. Jean-Paul G. Vonsattel8,
  11. Qian Sun9,10,
  12. Elan D. Louis11,12,
  13. Phyllis L. Faust8 and
  14. Sheng-Han Kuo6,13,*
  1. 1Department of Medical Research, National Taiwan University Hospital, Taipei City 10002, Taiwan.
  2. 2Institute of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei City 10051, Taiwan.
  3. 3Neurobiology and Cognitive Science Center, National Taiwan University, Taipei City 10051, Taiwan.
  4. 4Molecular Imaging Center, National Taiwan University, Taipei City 10051, Taiwan.
  5. 5Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin 64041, Taiwan.
  6. 6Department of Neurology, Columbia University, New York, NY 10032, USA.
  7. 7Department of Pediatrics, Taipei Tzu Chi Hospital, Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
  8. 8Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
  9. 9Department of Neuroscience, Columbia University, New York, NY 10032, USA.
  10. 10Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44016, USA.
  11. 11Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06519, USA.
  12. 12Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.
  13. 13Initiative of Columbia Ataxia and Tremor, New York, NY 10032, USA.
  1. *Corresponding author. Email: emorymkpan{at}ntu.edu.tw (M.-K.P.); sk3295{at}columbia.edu (S.-H.K.)

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