Research ArticleCancer

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

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Science Translational Medicine  15 Jan 2020:
Vol. 12, Issue 526, eaax9340
DOI: 10.1126/scitranslmed.aax9340

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Just as the tumor microenvironment influences the behavior of solid tumors, hematological malignancies are affected by the microenvironment in the bone marrow stroma. Park et al. identified a pathway dependent on protein kinase C-β from the stromal cells, which promotes survival and drug resistance in B cell malignancies. The authors examined the mechanism for the observed effects and then identified small-molecule compounds for potential intervention. Inhibiting the protein kinase C-β signaling pathway in stromal cells sensitized these cancers to a variety of drugs and extended survival in both genetic and patient-derived mouse models of cancer.

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