Research ArticleCancer

Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade

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Science Translational Medicine  15 Jan 2020:
Vol. 12, Issue 526, eaax7992
DOI: 10.1126/scitranslmed.aax7992

Article Information

vol. 12 no. 526

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 24, 2019
  • Resubmitted October 16, 2019
  • Accepted for publication December 16, 2019
  • .

Author Information

  1. Shinsuke Nakao1,*,
  2. Yukinori Arai1,
  3. Mamoru Tasaki1,
  4. Midori Yamashita1,
  5. Ryuji Murakami1,
  6. Tatsuya Kawase1,
  7. Nobuaki Amino1,
  8. Motomu Nakatake2,
  9. Hajime Kurosaki2,
  10. Masamichi Mori1,
  11. Masahiro Takeuchi1 and
  12. Takafumi Nakamura2
  1. 1Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba 305-8585, Japan.
  2. 2Department of Biomedical Science, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan.
  1. *Corresponding author. Email: shinsuke.nakao{at}astellas.com

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