Research ArticleStem Cell Transplantation

Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

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Science Translational Medicine  15 Jan 2020:
Vol. 12, Issue 526, eaax6249
DOI: 10.1126/scitranslmed.aax6249

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Mutant clones CHIPping in

Clonal hematopoiesis of indeterminate potential, or CHIP, is characterized by the presence of mutant hematopoietic stem cell clones in the bone marrow without overt signs of disease. However, emerging evidence suggests that this condition, which is more common in older patients, may not be as innocuous as previously thought, with recent studies connecting CHIP to a variety of medical problems. Using state-of-the-art gene sequencing methods, Wong et al. detected potentially pathogenic rare clonal mutations in samples from hematopoietic stem cell donors of various ages and showed that these persisted in the transplant recipients, raising questions about their implications for the recipients’ health outcomes.

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