Research ArticleISLET TRANSPLANTATION

Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization

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Science Translational Medicine  15 Jan 2020:
Vol. 12, Issue 526, eaan5907
DOI: 10.1126/scitranslmed.aan5907

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Improving islet transplantation

Pancreatic islet transplantation can stabilize blood glucose in individuals with type 1 diabetes; however, transplant function decreases occur over time, and suitable donor islet availability remains limited. Forbes et al. investigated the supportive effects of cotransplanting islets and perivascular mesenchymal stromal cells isolated from human umbilical cords (HUCPVCs). The HUCPVCs inhibited T cells and expressed proregenerative and immunoregulatory markers in vitro and increased islet vascularization in vivo. Cotransplanting human islets and HUCPVCs under the kidney capsule or via the hepatic portal vein improved control of blood glucose in diabetic immunodeficient and immunocompetent mouse models for up to 16 weeks. Results suggest that HUCPVCs could help improve long-term islet transplant function.

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