Research ArticleCardiology

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

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Science Translational Medicine  08 Jan 2020:
Vol. 12, Issue 525, eaay7205
DOI: 10.1126/scitranslmed.aay7205

Article Information

vol. 12 no. 525

Print ISSN: 
Online ISSN: 
  • Received for publication July 12, 2019
  • Resubmitted September 23, 2019
  • Accepted for publication December 3, 2019
  • .

Author Information

  1. Markus Wallner1,2,3,
  2. Deborah M. Eaton1,
  3. Remus M. Berretta1,
  4. Laura Liesinger4,5,6,
  5. Matthias Schittmayer4,5,6,
  6. Juergen Gindlhuber4,5,6,
  7. Jichuan Wu7,*,
  8. Mark Y. Jeong8,
  9. Ying H. Lin8,
  10. Giulia Borghetti1,,
  11. Sandy T. Baker7,,
  12. Huaqing Zhao9,
  13. Jessica Pfleger10,
  14. Sandra Blass4,
  15. Peter P. Rainer2,
  16. Dirk von Lewinski2,
  17. Heiko Bugger2,
  18. Sadia Mohsin1,
  19. Wolfgang F. Graier4,
  20. Andreas Zirlik2,
  21. Timothy A. McKinsey8,
  22. Ruth Birner-Gruenberger4,5,6,11,
  23. Marla R. Wolfson7 and
  24. Steven R. Houser1,§
  1. 1Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
  2. 2Division of Cardiology, Medical University of Graz, Graz 8036, Austria.
  3. 3Center for Biomarker Research in Medicine, CBmed GmbH, Graz 8010, Austria.
  4. 4Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz 8036, Austria.
  5. 5Institute of Pathology, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz, Graz 8036, Austria.
  6. 6Omics Center Graz, BioTechMed-Graz, Graz 8010, Austria.
  7. 7CENTRe: Consortium for Environmental and Neonatal Therapeutics Research, Lewis Katz School of Medicine, Department of Physiology, Department of Thoracic Medicine and Surgery, Pediatrics, Center for Inflammation, Translational and Clinical Lung Research, Temple University, Philadelphia, PA 19140, USA.
  8. 8Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  9. 9Department of Clinical Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
  10. 10Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
  11. 11Institute of Chemical Technology and Analytical Chemistry, Vienna University of Technology, Vienna 1060, Austria.
  1. §Corresponding author. Email: srhouser{at}
  • * Present address: Pulmonary, Allergy, and Critical Care Division, and Systems Pharmacology and Translational Therapeutics Department, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.

  • Present address: Novo Nordisk A/S, Måløv 2760, Denmark.

  • Present address: Research Integrity and Assurance, Princeton University, Princeton, NJ 08544, USA.


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