Research ArticleCardiology

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

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Science Translational Medicine  08 Jan 2020:
Vol. 12, Issue 525, eaay7205
DOI: 10.1126/scitranslmed.aay7205

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Counteracting cardiopulmonary dysfunction

In patients with heart failure, impaired relaxation of the left ventricle (diastolic dysfunction) results in incomplete filling with blood and increased pressure. Wallner et al. treated a feline model of slow-progressive pressure-overload–induced diastolic dysfunction with the histone deacetylase inhibitor SAHA. SAHA increased myofibril relaxation, improved pulmonary function, reduced left ventricular filling pressures, and reduced left ventricle hypertrophy in cats. The authors determined that SAHA altered acetylation of mitochondrial enzymes, resulting in enhanced mitochondrial respiration. Results suggest that histone deacetylase inhibition could potentially be beneficial for improving cardiopulmonary function.

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