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Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

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Science Translational Medicine  08 Jan 2020:
Vol. 12, Issue 525, eaay4860
DOI: 10.1126/scitranslmed.aay4860

Article Information

vol. 12 no. 525

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 22, 2019
  • Accepted for publication November 18, 2019
  • .

Author Information

  1. Alessandra Metelli1,
  2. Bill X. Wu2,
  3. Brian Riesenberg2,
  4. Silvia Guglietta1,
  5. John D. Huck3,
  6. Catherine Mills1,
  7. Anqi Li2,
  8. Saleh Rachidi1,
  9. Carsten Krieg1,
  10. Mark P. Rubinstein1,4,
  11. Daniel T. Gewirth3,
  12. Shaoli Sun5,
  13. Michael B. Lilly6,
  14. Amy H. Wahlquist7,
  15. David P. Carbone2,8,
  16. Yiping Yang2,9,
  17. Bei Liu1 and
  18. Zihai Li1,2,8,*
  1. 1Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  2. 2Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
  3. 3Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA.
  4. 4Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
  5. 5Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  6. 6Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  7. 7Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
  8. 8Division of Medical Oncology, The Ohio State University, Columbus, OH 43210, USA.
  9. 9Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH 43210, USA.
  1. *Corresponding author. Email: zihai.li{at}osumc.edu

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Article usage: January 2020 to August 2020

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Feb 202021795103
Mar 202025010080
Apr 20202125064
May 20201946886
Jun 20201576545
Jul 20201184024
Aug 2020341111

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