Research ArticleCancer

A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

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Science Translational Medicine  08 Jan 2020:
Vol. 12, Issue 525, eaaw7888
DOI: 10.1126/scitranslmed.aaw7888

Double trouble for tumors

Bispecific antibodies, which have one arm that binds to a cancer cell antigen and one arm that binds to CD3 on T cells, can help T cells recognize and eliminate cancer cells. However, they are not always sufficient to activate the T cells. To provide a boost to their activity, Skokos et al. designed a second type of bispecific antibodies that bind tumor antigens on one side and a T cell costimulatory receptor on the other side. These costimulatory bispecific antibodies had little activity alone but were effective in combination with CD3-targeting bispecific antibodies in multiple mouse models while showing no toxicity in mice or primates.

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