08 January 2020
Vol 12, Issue 525

About The Cover

Cover image expansion

ONLINE COVER A Two-pronged Attack. The illustration shows two examples of combination immunotherapy using bispecific antibodies. Bispecific antibodies (three-sided shapes in the image) recognize the protein markers CD3 or CD28 on T cells (green) as well as tumor antigens, thus bringing T cells into proximity with ovarian or prostate cancer cells (pink and multicolored cells, respectively). Skokos et al. found that combining the anti-CD3 and anti-CD28 bispecific antibodies enhanced the killing activity of T cells and boosted the antitumor immune response in mice. [CREDIT: EMILIE CLARK]