Research ArticleCancer
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
- View ORCID ProfileHuiyan Luo1,*,
- View ORCID ProfileQi Zhao1,*,
- View ORCID ProfileWei Wei1,*,
- View ORCID ProfileLianghong Zheng2,*,
- View ORCID ProfileShaohua Yi3,*,
- Gen Li4,
- Wenqiu Wang5,
- Hui Sheng1,
- Hengying Pu1,
- Haiyu Mo1,
- View ORCID ProfileZhixiang Zuo1,
- View ORCID ProfileZexian Liu1,
- Chaofeng Li1,
- Chuanbo Xie1,
- View ORCID ProfileZhaolei Zeng1,
- View ORCID ProfileWeimin Li6,
- Xiaoke Hao7,
- Yuying Liu1,
- Sumei Cao1,
- Wanli Liu1,
- View ORCID ProfileSarah Gibson4,
- Kang Zhang6,8,
- Guoliang Xu1 and
- View ORCID ProfileRui-hua Xu1,†
- 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
- 2Guangzhou Youze Biological Pharmaceutical Technology Company Ltd., Guangzhou 510005, P.R. China.
- 3Huazhong University of Science and Technology Tongji Medical College, Wuhan 430030, P. R. China.
- 4Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.
- 5Shanghai General Hospital, Shanghai 200080, P. R. China.
- 6Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
- 7Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
- 8Faculty of Medicine, Macau University of Science and Technology, Macau 999078, P. R. China.
- ↵†Corresponding author. Email: xurh{at}sysucc.org.cn
↵* These authors contributed equally to this work.
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Science Translational Medicine 01 Jan 2020:
Vol. 12, Issue 524, eaax7533
DOI: 10.1126/scitranslmed.aax7533
Vol. 12, Issue 524, eaax7533
DOI: 10.1126/scitranslmed.aax7533
Huiyan Luo
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Qi Zhao
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Wei Wei
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Lianghong Zheng
2Guangzhou Youze Biological Pharmaceutical Technology Company Ltd., Guangzhou 510005, P.R. China.
Shaohua Yi
3Huazhong University of Science and Technology Tongji Medical College, Wuhan 430030, P. R. China.
Gen Li
4Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.
Wenqiu Wang
5Shanghai General Hospital, Shanghai 200080, P. R. China.
Hui Sheng
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Hengying Pu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Haiyu Mo
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Zhixiang Zuo
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Zexian Liu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Chaofeng Li
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Chuanbo Xie
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Zhaolei Zeng
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Weimin Li
6Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
Xiaoke Hao
7Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Yuying Liu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Sumei Cao
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Wanli Liu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Sarah Gibson
4Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.
Kang Zhang
6Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
8Faculty of Medicine, Macau University of Science and Technology, Macau 999078, P. R. China.
Guoliang Xu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
Rui-hua Xu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
