Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

Huiyan Luo; Qi Zhao; Wei Wei; Lianghong Zheng; Shaohua Yi; Gen Li; Wenqiu Wang; Hui Sheng; Hengying Pu; Haiyu Mo; Zhixiang Zuo; Zexian Liu; Chaofeng Li; Chuanbo Xie; Zhaolei Zeng; Weimin Li; Xiaoke Hao; Yuying Liu; Sumei Cao; Wanli Liu; Sarah Gibson; Kang Zhang; Guoliang Xu; Rui-hua Xu

doi:10.1126/scitranslmed.aax7533

Research ArticleCancer

Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

Huiyan Luo ¹,*,
Qi Zhao¹,*,
Wei Wei ¹,*,
Lianghong Zheng²,*,
Shaohua Yi³,*,
Gen Li⁴,
Wenqiu Wang⁵,
Hui Sheng¹,
Hengying Pu¹,
Haiyu Mo¹,
Zhixiang Zuo¹,
Zexian Liu¹,
Chaofeng Li¹,
Chuanbo Xie¹,
Zhaolei Zeng¹,
Weimin Li⁶,
Xiaoke Hao⁷,
Yuying Liu¹,
Sumei Cao¹,
Wanli Liu¹,
Sarah Gibson⁴,
Kang Zhang⁶,⁸,
Guoliang Xu¹ and
Rui-hua Xu ¹,†

¹Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.
²Guangzhou Youze Biological Pharmaceutical Technology Company Ltd., Guangzhou 510005, P.R. China.
³Huazhong University of Science and Technology Tongji Medical College, Wuhan 430030, P. R. China.
⁴Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.
⁵Shanghai General Hospital, Shanghai 200080, P. R. China.
⁶Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
⁷Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
⁸Faculty of Medicine, Macau University of Science and Technology, Macau 999078, P. R. China.

↵†Corresponding author. Email: xurh{at}sysucc.org.cn

↵* These authors contributed equally to this work.

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Science Translational Medicine 01 Jan 2020:
Vol. 12, Issue 524, eaax7533
DOI: 10.1126/scitranslmed.aax7533

Huiyan Luo

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Qi Zhao

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Wei Wei

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Lianghong Zheng

2Guangzhou Youze Biological Pharmaceutical Technology Company Ltd., Guangzhou 510005, P.R. China.

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Shaohua Yi

3Huazhong University of Science and Technology Tongji Medical College, Wuhan 430030, P. R. China.

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Gen Li

4Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.

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Wenqiu Wang

5Shanghai General Hospital, Shanghai 200080, P. R. China.

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Hui Sheng

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Hengying Pu

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Haiyu Mo

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Zhixiang Zuo

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Zexian Liu

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Chaofeng Li

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Chuanbo Xie

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Zhaolei Zeng

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Weimin Li

6Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.

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Xiaoke Hao

7Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.

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Yuying Liu

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Sumei Cao

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Wanli Liu

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Sarah Gibson

4Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.

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Kang Zhang

6Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.

8Faculty of Medicine, Macau University of Science and Technology, Macau 999078, P. R. China.

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Guoliang Xu

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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Rui-hua Xu

1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

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For correspondence: xurh@sysucc.org.cn

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