Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice

Alicja A. Skowronski; Charles A. LeDuc; Kylie S. Foo; Yossef Goffer; Lisa C. Burnett; Dieter Egli; Rudolph L. Leibel

doi:10.1126/scitranslmed.aax6629

Research ArticleObesity

Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice

Alicja A. Skowronski ¹,
Charles A. LeDuc ¹,²,
Kylie S. Foo¹,*,
Yossef Goffer ¹,
Lisa C. Burnett¹,†,
Dieter Egli¹,²,³ and
Rudolph L. Leibel ¹,²,‡

¹Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
²Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
³Department of Obstetrics and Gynecology, and Columbia Stem Cell Initiative, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

↵‡Corresponding author. Email: rl232{at}cumc.columbia.edu

↵* Present address: Department of Medicine, Karolinska Institutet, Huddinge 14157 Sweden.
↵† Present address: Levo Therapeutics Inc., Chicago, IL 60077, USA.

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Science Translational Medicine 01 Jan 2020:
Vol. 12, Issue 524, eaax6629
DOI: 10.1126/scitranslmed.aax6629

Alicja A. Skowronski

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

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ORCID record for Alicja A. Skowronski

Charles A. LeDuc

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

2Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

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Kylie S. Foo

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

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Yossef Goffer

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

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Lisa C. Burnett

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

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Dieter Egli

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

2Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

3Department of Obstetrics and Gynecology, and Columbia Stem Cell Initiative, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

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Rudolph L. Leibel

1Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

2Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

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For correspondence: rl232@cumc.columbia.edu

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Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice

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