Research ArticleWound Healing

A dual-action peptide-containing hydrogel targets wound infection and inflammation

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Science Translational Medicine  01 Jan 2020:
Vol. 12, Issue 524, eaax6601
DOI: 10.1126/scitranslmed.aax6601

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Double defense

Wound infections can increase risk of systemic complications, such as sepsis, and can be difficult to treat due to growing antimicrobial resistance. Puthia et al. developed a hydrogel containing a thrombin-derived peptide, TCP-25, that kills bacteria and reduces inflammation. The hydrogel was effective against Staphylococcus aureus, Pseudomonas aeruginosa, and clinical bacterial isolates in vitro, and treated murine models of subcutaneous infections and porcine partial thickness wound infections. Bioactive cleavage fragments of the peptide were similar to those found in human wound fluid. Results suggest that this dual-action anti-inflammatory and antibacterial peptide-functionalized hydrogel is a promising approach for wound healing.

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