Helminth infections drive heterogeneity in human type 2 and regulatory cells

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Science Translational Medicine  01 Jan 2020:
Vol. 12, Issue 524, eaaw3703
DOI: 10.1126/scitranslmed.aaw3703

Parasite perturbation of immunity

Helminths infect billions of people and are known to modulate host immune responses to promote their survival. De Ruiter et al. used mass cytometry to gain a better understanding of which cells are affected by helminth infection. They analyzed samples from rural Indonesians before and after deworming treatment. These were compared to samples from Europeans and urban Indonesians, neither of which had been exposed to helminths. Helminths expanded specific type 2 and regulatory cells; many immune alterations reverted upon deworming. These details on host-pathogen interaction could inform future targeted therapies.

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