01 January 2020
Vol 12, Issue 524

About The Cover

Cover image expansion

ONLINE COVER Battling Bacteria and Inhibiting Inflammation. Wound healing can be hampered by infection and inflammation. This pseudocolored scanning electron microscopy image depicts the surface of a porcine skin wound infected with Staphylococcus aureus. Puthia et al. developed a hydrogel containing a thrombin-derived peptide (TCP-25) that has antibacterial and anti-inflammatory properties. The hydrogel killed clinical bacterial isolates in vitro, resolved subcutaneous infections and inflammation in mice, and hastened healing of infected skin wounds in pigs. This dual-action peptide-containing hydrogel could help improve wound healing. [CREDIT: PUTHIA ET AL./ SEBASTIAN WASSERSTROM, LUND UNIVERSITY BIOIMAGING CENTER]