Contents
01 January 2020
Vol 12, Issue 524
Vol 12, Issue 524
Research Articles
- A dual-action peptide-containing hydrogel targets wound infection and inflammation
A peptide-containing hydrogel treats both wound infection and inflammation.
- Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET
Tau imaging with [18F]flortaucipir predicts the severity and topography of subsequent MRI cortical atrophy in patients with Alzheimer’s disease.
- Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction
Recombinant human platelet-derived growth factor-AB improves cardiac function and survival after myocardial infarction in a porcine model.
- Helminth infections drive heterogeneity in human type 2 and regulatory cells
Mass cytometry identifies clusters of type 2 and regulatory immune responses in pre– and post–anthelmintic treatment human blood samples.
- Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
Circulating tumor DNA methylation–based signatures are potential biomarkers for early diagnosis and prognosis of colorectal cancer.
- Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice
Hyperleptinemia without weight gain during the immediate postnatal period exacerbates later diet-induced obesity in male and female mice.
Editors' Choice
- Drilling down in the fight against bacterial superbugs
Light-activated molecular nanomachines can resensitize antibiotic-resistant bacteria to antibiotics by drilling holes in their cell wall.
- Seizing control of fragile X syndrome
Loss of Fmr1 in glutamatergic neurons of the inferior colliculus is responsible for audiogenic seizures in the fragile X syndrome mouse model.
- Doubling down on tumor suppressor deletion
Codeletion of BRCA2 and RB1 increases prostate cancer sensitivity to PARP inhibitor therapy.
About The Cover
ONLINE COVER Battling Bacteria and Inhibiting Inflammation. Wound healing can be hampered by infection and inflammation. This pseudocolored scanning electron microscopy image depicts the surface of a porcine skin wound infected with Staphylococcus aureus. Puthia et al. developed a hydrogel containing a thrombin-derived peptide (TCP-25) that has antibacterial and anti-inflammatory properties. The hydrogel killed clinical bacterial isolates in vitro, resolved subcutaneous infections and inflammation in mice, and hastened healing of infected skin wounds in pigs. This dual-action peptide-containing hydrogel could help improve wound healing. [CREDIT: PUTHIA ET AL./ SEBASTIAN WASSERSTROM, LUND UNIVERSITY BIOIMAGING CENTER]
