Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

Kevin J. McHugh; Lihong Jing; Sean Y. Severt; Mache Cruz; Morteza Sarmadi; Hapuarachchige Surangi N. Jayawardena; Collin F. Perkinson; Fridrik Larusson; Sviatlana Rose; Stephanie Tomasic; Tyler Graf; Stephany Y. Tzeng; James L. Sugarman; Daniel Vlasic; Matthew Peters; Nels Peterson; Lowell Wood; Wen Tang; Jihyeon Yeom; Joe Collins; Philip A. Welkhoff; Ari Karchin; Megan Tse; Mingyuan Gao; Moungi G. Bawendi; Robert Langer; Ana Jaklenec

doi:10.1126/scitranslmed.aay7162

Research ArticleBioengineering

Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

View ORCID ProfileKevin J. McHugh ¹,*,†,
View ORCID ProfileLihong Jing ¹,²,*,
View ORCID ProfileSean Y. Severt¹,
View ORCID ProfileMache Cruz¹,
Morteza Sarmadi¹,³,
View ORCID ProfileHapuarachchige Surangi N. Jayawardena¹,‡,
View ORCID ProfileCollin F. Perkinson ⁴,
View ORCID ProfileFridrik Larusson⁵,
Sviatlana Rose¹,
View ORCID ProfileStephanie Tomasic¹,
View ORCID ProfileTyler Graf¹,
Stephany Y. Tzeng¹,§,
View ORCID ProfileJames L. Sugarman¹,
Daniel Vlasic⁶,
View ORCID ProfileMatthew Peters⁵,
View ORCID ProfileNels Peterson⁵,
View ORCID ProfileLowell Wood⁵,
Wen Tang¹,
View ORCID ProfileJihyeon Yeom¹,
View ORCID ProfileJoe Collins¹,
Philip A. Welkhoff⁷,
Ari Karchin⁵,
View ORCID ProfileMegan Tse¹,
Mingyuan Gao²,
View ORCID ProfileMoungi G. Bawendi⁴,
View ORCID ProfileRobert Langer ¹,|| and
View ORCID ProfileAna Jaklenec¹,||

¹Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
²Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing 100190, China.
³Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
⁴Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
⁵Global Good, Intellectual Ventures Laboratory, 14360 SE Eastgate Way, Bellevue, WA 98007, USA.
⁶Independent consultant, 119 Kendall Rd, Lexington, MA 02421, USA (https://people.csail.mit.edu/drdaniel/).
⁷Institute for Disease Modeling, 3150 139th Ave. SE, Bellevue, WA 98005, USA.

↵||Corresponding author. Email: rlanger{at}mit.edu (R.L.); jaklenec{at}mit.edu (A.J.)

↵* These authors contributed equally to this work.
↵† Present address: Department of Bioengineering, Rice University, Houston, TX 77005, USA.
↵‡ Present address: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
↵§ Present address: School of Medicine, Johns Hopkins University, 733 N. Broadway, Baltimore, MD 21205, USA.

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Science Translational Medicine 18 Dec 2019:
Vol. 11, Issue 523, eaay7162
DOI: 10.1126/scitranslmed.aay7162

Kevin J. McHugh

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Lihong Jing

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

2Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing 100190, China.

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Sean Y. Severt

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Mache Cruz

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Morteza Sarmadi

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

3Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Hapuarachchige Surangi N. Jayawardena

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Collin F. Perkinson

4Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Fridrik Larusson

5Global Good, Intellectual Ventures Laboratory, 14360 SE Eastgate Way, Bellevue, WA 98007, USA.

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Sviatlana Rose

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Stephanie Tomasic

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Tyler Graf

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Stephany Y. Tzeng

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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James L. Sugarman

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Daniel Vlasic

6Independent consultant, 119 Kendall Rd, Lexington, MA 02421, USA ().

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Matthew Peters

5Global Good, Intellectual Ventures Laboratory, 14360 SE Eastgate Way, Bellevue, WA 98007, USA.

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Nels Peterson

5Global Good, Intellectual Ventures Laboratory, 14360 SE Eastgate Way, Bellevue, WA 98007, USA.

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Lowell Wood

5Global Good, Intellectual Ventures Laboratory, 14360 SE Eastgate Way, Bellevue, WA 98007, USA.

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Wen Tang

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Jihyeon Yeom

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Joe Collins

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Philip A. Welkhoff

7Institute for Disease Modeling, 3150 139th Ave. SE, Bellevue, WA 98005, USA.

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Ari Karchin

5Global Good, Intellectual Ventures Laboratory, 14360 SE Eastgate Way, Bellevue, WA 98007, USA.

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Megan Tse

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Mingyuan Gao

2Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing 100190, China.

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Moungi G. Bawendi

4Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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Robert Langer

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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For correspondence: rlanger@mit.edu jaklenec@mit.edu

Ana Jaklenec

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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For correspondence: rlanger@mit.edu jaklenec@mit.edu

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Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

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