Research ArticleBioengineering

Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

See allHide authors and affiliations

Science Translational Medicine  18 Dec 2019:
Vol. 11, Issue 523, eaay7162
DOI: 10.1126/scitranslmed.aay7162

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

On the record

Vaccines prevent disease and save lives; however, lack of standardized immunization recordkeeping makes it challenging to track vaccine coverage across the world. McHugh et al. developed dissolvable microneedles that deliver patterns of near-infrared light-emitting microparticles to the skin. Particle patterns are invisible to the eye but can be imaged using modified smartphones. By codelivering a vaccine, the pattern of particles in the skin could serve as an on-person vaccination record. Patterns were detected 9 months after intradermal delivery of microparticles in rats, and codelivery of inactivated poliovirus led to protective antibody production. Discrete microneedle-delivered microparticle patterns in porcine and pigmented human skin were identifiable using semiautomated machine learning. These results demonstrate proof of concept for intradermal on-person vaccination recordkeeping.

View Full Text

Stay Connected to Science Translational Medicine