Research ArticleHIV
Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells
- View ORCID ProfileSon Nguyen1,
- View ORCID ProfileClaire Deleage2,
- View ORCID ProfileSamuel Darko3,
- Amy Ransier3,
- View ORCID ProfileDuc P. Truong4,
- View ORCID ProfileDivyansh Agarwal5,
- View ORCID ProfileAlberto Sada Japp1,
- View ORCID ProfileVincent H. Wu1,
- View ORCID ProfileLeticia Kuri-Cervantes1,
- View ORCID ProfileMohamed Abdel-Mohsen6,
- View ORCID ProfilePerla M. Del Rio Estrada7,
- Yuria Ablanedo-Terrazas7,
- View ORCID ProfileEmma Gostick8,
- View ORCID ProfileJames A. Hoxie9,
- View ORCID ProfileNancy R. Zhang5,
- View ORCID ProfileAli Naji10,
- View ORCID ProfileGustavo Reyes-Terán7,
- View ORCID ProfileJacob D. Estes11,12,
- View ORCID ProfileDavid A. Price8,
- Daniel C. Douek3,
- View ORCID ProfileSteven G. Deeks13,
- View ORCID ProfileMarcus Buggert14,* and
- View ORCID ProfileMichael R. Betts1,*,†
- 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.
- 3Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 4Department of Mathematics, Southern Methodist University, Dallas, TX 75205, USA.
- 5Department of Statistics, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 6The Wistar Institute, Philadelphia, PA 19104, USA.
- 7Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
- 8Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
- 9Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 10Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 11Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97239, USA.
- 12Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR 97239, USA.
- 13Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94110, USA.
- 14Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
- ↵†Corresponding author. Email: betts{at}pennmedicine.upenn.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 18 Dec 2019:
Vol. 11, Issue 523, eaax4077
DOI: 10.1126/scitranslmed.aax4077
Vol. 11, Issue 523, eaax4077
DOI: 10.1126/scitranslmed.aax4077
Son Nguyen
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Claire Deleage
2AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.
Samuel Darko
3Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Amy Ransier
3Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Duc P. Truong
4Department of Mathematics, Southern Methodist University, Dallas, TX 75205, USA.
Divyansh Agarwal
5Department of Statistics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alberto Sada Japp
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Vincent H. Wu
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leticia Kuri-Cervantes
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mohamed Abdel-Mohsen
6The Wistar Institute, Philadelphia, PA 19104, USA.
Perla M. Del Rio Estrada
7Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
Yuria Ablanedo-Terrazas
7Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
Emma Gostick
8Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
James A. Hoxie
9Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nancy R. Zhang
5Department of Statistics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ali Naji
10Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gustavo Reyes-Terán
7Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
Jacob D. Estes
11Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97239, USA.
12Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR 97239, USA.
David A. Price
8Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Daniel C. Douek
3Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Steven G. Deeks
13Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94110, USA.
Marcus Buggert
14Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Michael R. Betts
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
