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Research ArticleCancer
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition
- View ORCID ProfileNa Kong1,2,*,
- View ORCID ProfileWei Tao1,*,†,
- Xiang Ling1,
- View ORCID ProfileJunqing Wang1,
- Yuling Xiao1,
- Sanjun Shi1,
- Xiaoyuan Ji1,3,
- Aram Shajii1,
- Silvia Tian Gan1,4,
- View ORCID ProfileNa Yoon Kim1,
- View ORCID ProfileDan G. Duda5,
- View ORCID ProfileTian Xie3,†,
- View ORCID ProfileOmid C. Farokhzad1,6,† and
- View ORCID ProfileJinjun Shi1,†
- 1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 2School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
- 3Department of Cancer Pharmacology, Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
- 4Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
- 5Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 6King Abdulaziz University, Jeddah 21589, Saudi Arabia.
- ↵†Corresponding author. Email: wtao{at}bwh.harvard.edu (W.T.); tianxie{at}hznu.edu.cn (T.X.); ofarokhzad{at}bwh.harvard.edu (O.C.F.); jshi{at}bwh.harvard.edu (J.S.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 18 Dec 2019:
Vol. 11, Issue 523, eaaw1565
DOI: 10.1126/scitranslmed.aaw1565
Vol. 11, Issue 523, eaaw1565
DOI: 10.1126/scitranslmed.aaw1565
Na Kong
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
2School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Wei Tao
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xiang Ling
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Junqing Wang
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yuling Xiao
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sanjun Shi
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xiaoyuan Ji
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
3Department of Cancer Pharmacology, Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Aram Shajii
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Silvia Tian Gan
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
4Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Na Yoon Kim
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dan G. Duda
5Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Tian Xie
3Department of Cancer Pharmacology, Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Omid C. Farokhzad
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
6King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Jinjun Shi
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
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