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Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

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Science Translational Medicine  18 Dec 2019:
Vol. 11, Issue 523, eaaw1565
DOI: 10.1126/scitranslmed.aaw1565

Article Information

vol. 11 no. 523

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 2, 2018
  • Resubmitted August 23, 2019
  • Accepted for publication November 20, 2019
  • .

Author Information

  1. Na Kong1,2,*,
  2. Wei Tao1,*,,
  3. Xiang Ling1,
  4. Junqing Wang1,
  5. Yuling Xiao1,
  6. Sanjun Shi1,
  7. Xiaoyuan Ji1,3,
  8. Aram Shajii1,
  9. Silvia Tian Gan1,4,
  10. Na Yoon Kim1,
  11. Dan G. Duda5,
  12. Tian Xie3,,
  13. Omid C. Farokhzad1,6, and
  14. Jinjun Shi1,
  1. 1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  3. 3Department of Cancer Pharmacology, Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
  4. 4Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
  5. 5Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  6. 6King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  1. Corresponding author. Email: wtao{at}bwh.harvard.edu (W.T.); tianxie{at}hznu.edu.cn (T.X.); ofarokhzad{at}bwh.harvard.edu (O.C.F.); jshi{at}bwh.harvard.edu (J.S.)
  • * These authors contributed equally to this work.

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