Research ArticleAmyotrophic Lateral Sclerosis

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

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Science Translational Medicine  18 Dec 2019:
Vol. 11, Issue 523, eaav5264
DOI: 10.1126/scitranslmed.aav5264

Article Information

vol. 11 no. 523

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 26, 2018
  • Resubmitted July 11, 2019
  • Accepted for publication November 20, 2019
  • .

Author Information

  1. Irit Reichenstein1,*,
  2. Chen Eitan1,2,*,
  3. Sandra Diaz-Garcia3,
  4. Guy Haim1,
  5. Iddo Magen1,
  6. Aviad Siany1,
  7. Mariah L. Hoye4,
  8. Natali Rivkin1,
  9. Tsviya Olender1,
  10. Beata Toth1,
  11. Revital Ravid1,
  12. Amitai D. Mandelbaum1,
  13. Eran Yanowski1,
  14. Jing Liang1,
  15. Jeffrey K. Rymer5,6,
  16. Rivka Levy7,
  17. Gilad Beck8,
  18. Elena Ainbinder8,
  19. Sali M. K. Farhan9,10,
  20. Kimberly A. Lennox11,
  21. Nicole M. Bode11,
  22. Mark A. Behlke11,
  23. Thomas Möller12,
  24. Smita Saxena13,14,
  25. Cristiane A. M. Moreno15,
  26. Giancarlo Costaguta16,
  27. Kristel R. van Eijk2,17,
  28. Hemali Phatnani18,
  29. Ammar Al-Chalabi2,19,20,
  30. A. Nazli Başak2,21,
  31. Leonard H. van den Berg2,17,
  32. Orla Hardiman2,22,23,
  33. John E. Landers2,24,
  34. Jesus S. Mora2,25,
  35. Karen E. Morrison2,26,
  36. Pamela J. Shaw2,27,
  37. Jan H. Veldink2,17,
  38. Samuel L. Pfaff16,
  39. Ofer Yizhar7,
  40. Christina Gross5,6,
  41. Robert H. Brown Jr.28,
  42. John M. Ravits3,
  43. Matthew B. Harms15,
  44. Timothy M. Miller4 and
  45. Eran Hornstein1,2,
  1. 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  2. 2Project MinE ALS Sequencing Consortium.
  3. 3Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.
  4. 4Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  5. 5Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  6. 6Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  7. 7Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  8. 8Stem Cell Core and Advanced Cell Technologies Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
  9. 9Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  10. 10Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  11. 11Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
  12. 12Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
  13. 13Department of Neurology, Inselspital University Hospital, University of Bern, Freiburgstrasse 16, CH-3010 Bern, Bern, Switzerland.
  14. 14Department for BioMedical Research, University of Bern, Murtenstrasse 40, CH-3008 Bern, Switzerland.
  15. 15Department of Neurology, Columbia University, New York, NY 10032, USA.
  16. 16Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  17. 17Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.
  18. 18Center for Genomics of Neurodegenerative Disease (CGND) and New York Genome Center (NYGC) ALS Consortium, New York, NY 10013, USA.
  19. 19Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute, Department of Basic and Clinical Neuroscience, Department of Neurology, King’s College London, London SE5 9RX, UK.
  20. 20Department of Neurology, King’s College Hospital, London SE5 9RS, UK.
  21. 21Koç University Translational Medicine Research Center, NDAL, Istanbul 34010, Turkey.
  22. 22Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin 2, Republic of Ireland.
  23. 23Department of Neurology, Beaumont Hospital, Dublin 2, Republic of Ireland.
  24. 24Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  25. 25ALS Unit, Hospital San Rafael, Madrid 28016, Spain.
  26. 26Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
  27. 27Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK.
  28. 28Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  1. Corresponding author. Email: eran.hornstein{at}weizmann.ac.il
  • * These authors contributed equally to this work.

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