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Research ArticleAlzheimer’s Disease
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain
- View ORCID ProfileJeanna M. Wheeler1,*,
- View ORCID ProfilePamela McMillan2,*,
- View ORCID ProfileTimothy J. Strovas1,*,
- View ORCID ProfileNicole F. Liachko1,3,
- View ORCID ProfileAlexandre Amlie-Wolf4,
- View ORCID ProfileRebecca L. Kow1,3,
- Ronald L. Klein5,†,
- View ORCID ProfilePatricia Szot2,6,
- View ORCID ProfileLinda Robinson1,
- View ORCID ProfileChris Guthrie1,
- View ORCID ProfileAleen Saxton1,
- View ORCID ProfileNicholas M. Kanaan7,
- View ORCID ProfileMurray Raskind2,6,
- View ORCID ProfileElaine Peskind2,6,
- View ORCID ProfileJohn Q. Trojanowski4,
- Virginia M. Y. Lee4,
- View ORCID ProfileLi-San Wang4,
- View ORCID ProfileC. Dirk Keene8,
- Thomas Bird1,9,10,
- View ORCID ProfileGerard D. Schellenberg4 and
- View ORCID ProfileBrian Kraemer1,2,3,8,‡
- 1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
- 2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
- 3Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA.
- 4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
- 6Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
- 7Department of Translational Sciences and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
- 8Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
- 9Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA.
- 10Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98104, USA.
- ↵‡Corresponding author. Email: kraemerb{at}uw.edu
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Science Translational Medicine 18 Dec 2019:
Vol. 11, Issue 523, eaao6545
DOI: 10.1126/scitranslmed.aao6545
Vol. 11, Issue 523, eaao6545
DOI: 10.1126/scitranslmed.aao6545
Jeanna M. Wheeler
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Pamela McMillan
2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Timothy J. Strovas
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Nicole F. Liachko
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
3Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA.
Alexandre Amlie-Wolf
4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rebecca L. Kow
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
3Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA.
Ronald L. Klein
5Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
Patricia Szot
2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
6Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Linda Robinson
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Chris Guthrie
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Aleen Saxton
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Nicholas M. Kanaan
7Department of Translational Sciences and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
Murray Raskind
2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
6Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Elaine Peskind
2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
6Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
John Q. Trojanowski
4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Virginia M. Y. Lee
4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Li-San Wang
4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
C. Dirk Keene
8Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Thomas Bird
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
9Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA.
10Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98104, USA.
Gerard D. Schellenberg
4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Brian Kraemer
1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
3Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA.
8Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
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