Research ArticleAlzheimer’s Disease

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

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Science Translational Medicine  18 Dec 2019:
Vol. 11, Issue 523, eaao6545
DOI: 10.1126/scitranslmed.aao6545

Article Information

vol. 11 no. 523

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 14, 2017
  • Accepted for publication June 20, 2019
  • .

Author Information

  1. Jeanna M. Wheeler1,*,
  2. Pamela McMillan2,*,
  3. Timothy J. Strovas1,*,
  4. Nicole F. Liachko1,3,
  5. Alexandre Amlie-Wolf4,
  6. Rebecca L. Kow1,3,
  7. Ronald L. Klein5,,
  8. Patricia Szot2,6,
  9. Linda Robinson1,
  10. Chris Guthrie1,
  11. Aleen Saxton1,
  12. Nicholas M. Kanaan7,
  13. Murray Raskind2,6,
  14. Elaine Peskind2,6,
  15. John Q. Trojanowski4,
  16. Virginia M. Y. Lee4,
  17. Li-San Wang4,
  18. C. Dirk Keene8,
  19. Thomas Bird1,9,10,
  20. Gerard D. Schellenberg4 and
  21. Brian Kraemer1,2,3,8,
  1. 1Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
  2. 2Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
  3. 3Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA.
  4. 4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
  6. 6Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
  7. 7Department of Translational Sciences and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
  8. 8Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
  9. 9Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA.
  10. 10Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98104, USA.
  1. Corresponding author. Email: kraemerb{at}uw.edu
  • * These authors contributed equally to this work.

  • Deceased.

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