18 December 2019
Vol 11, Issue 523

About The Cover

Cover image expansion

ONLINE COVER On the Record. Poor immunization recordkeeping contributes to undervaccination and vaccine-preventable deaths, an issue of global concern. This image shows a microneedle patch (blue) delivering microparticle-encapsulated quantum dots (green) into skin. As an on-body record of vaccination, McHugh et al. developed dissolvable microneedle patches that codelivered poliovirus vaccine and microparticles that fluoresce when exposed to near-infrared light. Microparticles administered in distinct patterns to human or porcine skin ex vivo were invisible to the naked eye but could be detected by an adapted smartphone and did not interfere with production of neutralizing antibodies in vaccinated rats. This proof-of-concept study reports an easy-to-administer platform that could improve vaccination recordkeeping. [CREDIT: SECOND BAY STUDIOS]