Research ArticleCOAGULATION

Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications

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Science Translational Medicine  11 Dec 2019:
Vol. 11, Issue 522, eaay0203
DOI: 10.1126/scitranslmed.aay0203

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Strength in numbers (of platelets)

Platelet transfusions are effective at restoring hemostasis in patients with low platelet counts, but this tactic does not necessarily work in patients who have normal numbers of platelets but impaired platelet function resulting from genetic or drug-induced defects. Using mouse models and platelets from human patients, Lee et al. demonstrated that dysfunctional platelets can interfere with the formation and/or consolidation of a platelet plug at the site of injury, but this impairment can be overcome by providing wild-type platelets at a sufficiently high ratio.

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