PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

Xue Han; Matthew D. Vesely; Wendy Yang; Miguel F. Sanmamed; Ti Badri; Jude Alawa; Francesc López-Giráldez; Patricia Gaule; Sang Won Lee; Jian-Ping Zhang; Xinxin Nie; Ala Nassar; Agedi Boto; Dallas B. Flies; Linghua Zheng; Tae Kon Kim; Gilbert W. Moeckel; Jennifer M. McNiff; Lieping Chen

doi:10.1126/scitranslmed.aax1159

Research ArticleAutoimmunity

PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

Xue Han¹,*,
Matthew D. Vesely ¹,²,*,
Wendy Yang¹,
Miguel F. Sanmamed¹,
Ti Badri¹,
Jude Alawa¹,
Francesc López-Giráldez³,⁴,
Patricia Gaule⁵,
Sang Won Lee¹,
Jian-Ping Zhang¹,
Xinxin Nie¹,
Ala Nassar¹,
Agedi Boto¹,⁵,
Dallas B. Flies¹,
Linghua Zheng¹,
Tae Kon Kim¹,⁶,
Gilbert W. Moeckel⁵,
Jennifer M. McNiff²,⁵ and
Lieping Chen ¹,²,⁶,†

¹Department of Immunobiology, Yale University, New Haven, CT 06520, USA.
²Department of Dermatology, Yale University, New Haven, CT 06520, USA.
³Department of Genetics, Yale University, New Haven, CT 06520, USA.
⁴Yale Center for Genome Analysis, Yale University, New Haven, CT 06477, USA.
⁵Department of Pathology, Yale University, New Haven, CT 06520, USA.
⁶Department of Medicine, Yale University, New Haven, CT 06520, USA.

↵†Corresponding author. Email: lieping.chen{at}yale.edu

↵* Co-first authors.

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Science Translational Medicine 11 Dec 2019:
Vol. 11, Issue 522, eaax1159
DOI: 10.1126/scitranslmed.aax1159

Xue Han

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Matthew D. Vesely

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

Department of Dermatology, Yale University, New Haven, CT 06520, USA.

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Wendy Yang

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Miguel F. Sanmamed

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Ti Badri

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Jude Alawa

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Francesc López-Giráldez

Department of Genetics, Yale University, New Haven, CT 06520, USA.

Yale Center for Genome Analysis, Yale University, New Haven, CT 06477, USA.

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Patricia Gaule

Department of Pathology, Yale University, New Haven, CT 06520, USA.

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Sang Won Lee

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Jian-Ping Zhang

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Xinxin Nie

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Ala Nassar

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Agedi Boto

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

Department of Pathology, Yale University, New Haven, CT 06520, USA.

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Dallas B. Flies

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Linghua Zheng

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

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Tae Kon Kim

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

Department of Medicine, Yale University, New Haven, CT 06520, USA.

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Gilbert W. Moeckel

Department of Pathology, Yale University, New Haven, CT 06520, USA.

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Jennifer M. McNiff

Department of Dermatology, Yale University, New Haven, CT 06520, USA.

Department of Pathology, Yale University, New Haven, CT 06520, USA.

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Lieping Chen

Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

Department of Dermatology, Yale University, New Haven, CT 06520, USA.

Department of Medicine, Yale University, New Haven, CT 06520, USA.

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For correspondence: lieping.chen@yale.edu

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