Research ArticleAutoimmunity

PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

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Science Translational Medicine  11 Dec 2019:
Vol. 11, Issue 522, eaax1159
DOI: 10.1126/scitranslmed.aax1159

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Supporting a suppressor for lupus treatment

Autoimmunity can result when the intricate checks and balances in the immune system are disrupted. Han et al. discovered a potential treatment target for lupus erythematosus: the inhibitory receptor PD-1H. PD-1H knockout mice on a BALB/c background developed cutaneous lesions and were more susceptible to pristane-induced autoimmunity. Treating lupus-prone MRL/lpr mice with an antibody that activated PD-1H reduced skin symptoms and some markers of autoimmunity. The antibody was shown to act on myeloid cells and T cells and could potentially restore immune balance in patients with lupus.

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