A once-a-month oral contraceptive

Ameya R. Kirtane; Tiffany Hua; Alison Hayward; Ambika Bajpayee; Aniket Wahane; Aaron Lopes; Taylor Bensel; Lihong Ma; Frank Z. Stanczyk; Sierra Brooks; Declan Gwynne; Jacob Wainer; Joy Collins; Siddartha M. Tamang; Robert Langer; Giovanni Traverso

doi:10.1126/scitranslmed.aay2602

ReportDrug Delivery

A once-a-month oral contraceptive

Ameya R. Kirtane¹,²,*,
Tiffany Hua¹,²,*,
Alison Hayward¹,²,³,
Ambika Bajpayee⁴,
Aniket Wahane¹,²,
Aaron Lopes¹,²,
Taylor Bensel¹,²,
Lihong Ma⁵,
Frank Z. Stanczyk⁵,
Sierra Brooks¹,
Declan Gwynne¹,²,
Jacob Wainer¹,²,
Joy Collins¹,²,
Siddartha M. Tamang¹,²,
Robert Langer¹,²,⁶,⁷,⁸,† and
Giovanni Traverso ⁸,⁹,†

¹David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴Departments of Bioengineering and Mechanical Engineering, Northeastern University, Boston, MA 02115, USA.
⁵Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
⁶Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁷Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁸Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁹Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

↵†Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}bwh.harvard.edu, cgt20{at}mit.edu (G.T.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 04 Dec 2019:
Vol. 11, Issue 521, eaay2602
DOI: 10.1126/scitranslmed.aay2602

Ameya R. Kirtane

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Tiffany Hua

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Alison Hayward

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Ambika Bajpayee

Departments of Bioengineering and Mechanical Engineering, Northeastern University, Boston, MA 02115, USA.

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Aniket Wahane

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Aaron Lopes

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Taylor Bensel

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Lihong Ma

Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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Frank Z. Stanczyk

Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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Sierra Brooks

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Declan Gwynne

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Jacob Wainer

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Joy Collins

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Siddartha M. Tamang

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Robert Langer

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu

Giovanni Traverso

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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For correspondence: rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu

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