When less is more
Reducing the frequency at which a patient must take a medication can improve patient adherence. Kirtane et al. developed an ingestible gastric resident dosage form that releases the contraceptive levonorgestrel. Levonorgestrel was detected in the serum of pigs for 1 month after oral administration of a single dose. These preliminary results demonstrate progress that is an easy pill to swallow.
Abstract
Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.
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