04 December 2019
Vol 11, Issue 521

About The Cover

Cover image expansion

ONLINE COVER None Shall Pass. This illustration represents the blood-brain barrier (BBB), a tight-knit border of endothelial cells, pericytes, and astrocytes that separates the brain from the systemic circulation. Loss of BBB integrity contributes to neurological diseases, such as Alzheimer's disease (AD) and epilepsy and to cognitive impairment in aging. In this issue, a pair of studies investigated the effects of BBB dysfunction on neuronal networks and cognition. BBB impairments were spatially associated with electroencephalographic abnormalities in patients with AD or epilepsy and in aging mice (Milikovsky et al.). In aging rodents, cognitive impairments mediated by activation of TGFβ triggered by BBB leakage were restored by inhibiting TGFβ (Senatorov et al.). These studies highlight the importance of proper BBB function for maintaining neuronal homeostasis. [CREDIT: GUNILLA ELAM/SCIENCE SOURCE]