Focus10TH ANNIVERSARY SERIES

Promising disease-modifying therapies for Parkinson’s disease

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Science Translational Medicine  27 Nov 2019:
Vol. 11, Issue 520, eaba1659
DOI: 10.1126/scitranslmed.aba1659

Tables

  • Table 1 Agents in clinical trials for PD.

    TargetActionAgentTrial phaseClinical trial identifier
    LRRK2Decrease LRRK2 kinase
    activity
    Denali—DNL-151Phase 1NCT04056689
    Denali—DNL-201Phase 1NCT03710707
    GlucocerebrosidaseChemical chaperone to
    translocate mutant enzyme
    from the endoplasmic
    reticulum into lysosomes
    AmbroxolPhase 2NCT02941822 and NCT02914366
    Allergan—LTI-291Phase 1Netherlands Trial NL7061
    Block accumulation of the
    glucocerebrosidase
    substrate, glucosylceramide
    Genzyme/Sanofi—Ibiglustat
    (GZ/SAR40267)
    Phase 2NCT02906020
    α-SynucleinAnti–α-synuclein monoclonal
    antibodies to lower
    α-synuclein concentrations
    and block cell-to-cell
    transmission
    Biogen—CinpanemabPhase 1/2NCT03318523 and NCT03716570
    Hoffmann–La Roche/Prothena—
    Prasinezumab
    Phase 2NCT03100149
    Abbvie—ABBV 0805Phase 1NCT04127695
    Takeda/AstraZeneca—MEDI1341Phase 1NCT03272165
    Lundbeck—Lu-AF-82422Phase 1NCT03611569
    Inhibitors of pathological
    α-synuclein aggregation
    Enterin—ENT-01Phase 1NCT03938922
    Alterity Therapeutic—
    PBT434
    Phase 1U1111–1211-0052
    Neuropore Therapies Inc./UCB
    S.A.—NPT200-11
    Phase 1NCT02606682
    c-Abl kinasec-Abl kinase inhibitionSPARC—K0706Phase 2NCT03655236
    Novartis—NilotinibPhase 2NCT02954978 and NCT03205488
    1ST Biotherapeutics, Inc—FB-101Phase 1NCT04165837
    GLP-1 receptorGLP-1 receptor agonist,
    decreases inflammation
    Amylin Pharmaceutical/
    AstraZeneca—Exenatide
    Phase 3NCT03456687,
    NCT04154072, and
    ISRCTN14552789
    Novo Nordisk—LiraglutidePhase 2NCT02953665
    Sanofi—LixisenatidePhase 2NCT03439943
    Neuraly—NLY01Phase 2NCT04154072

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