Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Pilar Garcia-Broncano; Shivaali Maddali; Kevin B. Einkauf; Chenyang Jiang; Ce Gao; Joshua Chevalier; Fatema Z. Chowdhury; Kenneth Maswabi; Gbolahan Ajibola; Sikhulile Moyo; Terence Mohammed; Thabani Ncube; Joseph Makhema; Patrick Jean-Philippe; Xu G. Yu; Kathleen M. Powis; Shahin Lockman; Daniel R. Kuritzkes; Roger Shapiro; Mathias Lichterfeld

doi:10.1126/scitranslmed.aax7350

Research ArticleHIV

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

View ORCID ProfilePilar Garcia-Broncano¹,
View ORCID ProfileShivaali Maddali¹,
View ORCID ProfileKevin B. Einkauf¹,²,
View ORCID ProfileChenyang Jiang¹,²,
View ORCID ProfileCe Gao¹,
View ORCID ProfileJoshua Chevalier¹,²,
View ORCID ProfileFatema Z. Chowdhury¹,
Kenneth Maswabi³,
View ORCID ProfileGbolahan Ajibola³,
View ORCID ProfileSikhulile Moyo³,
Terence Mohammed³,
Thabani Ncube³,
Joseph Makhema³,
Patrick Jean-Philippe⁴,
View ORCID ProfileXu G. Yu ¹,²,⁵,
Kathleen M. Powis ³,⁵,⁶,⁷,
View ORCID ProfileShahin Lockman²,³,⁵,
Daniel R. Kuritzkes²,⁵,
View ORCID ProfileRoger Shapiro³,⁵,⁷ and
View ORCID ProfileMathias Lichterfeld ¹,²,⁵,*

¹Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
²Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
³Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
⁴Division of AIDS, NIAID, NIH, Rockville, MD 20852, USA.
⁵Harvard Medical School, Boston, MA 02115, USA.
⁶Departments of Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA.
⁷Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

↵*Corresponding author. Email: mlichterfeld{at}partners.org

See allHide authors and affiliations

Science Translational Medicine 27 Nov 2019:
Vol. 11, Issue 520, eaax7350
DOI: 10.1126/scitranslmed.aax7350

Pilar Garcia-Broncano

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Pilar Garcia-Broncano

Shivaali Maddali

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Shivaali Maddali

Kevin B. Einkauf

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kevin B. Einkauf

Chenyang Jiang

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chenyang Jiang

Ce Gao

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ce Gao

Joshua Chevalier

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joshua Chevalier

Fatema Z. Chowdhury

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fatema Z. Chowdhury

Kenneth Maswabi

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gbolahan Ajibola

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gbolahan Ajibola

Sikhulile Moyo

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sikhulile Moyo

Terence Mohammed

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thabani Ncube

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joseph Makhema

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patrick Jean-Philippe

4Division of AIDS, NIAID, NIH, Rockville, MD 20852, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xu G. Yu

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

5Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xu G. Yu

Kathleen M. Powis

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

5Harvard Medical School, Boston, MA 02115, USA.

6Departments of Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA.

7Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shahin Lockman

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

5Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Shahin Lockman

Daniel R. Kuritzkes

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

5Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Roger Shapiro

3Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

5Harvard Medical School, Boston, MA 02115, USA.

7Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Roger Shapiro

Mathias Lichterfeld

1Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

5Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mathias Lichterfeld
For correspondence: mlichterfeld@partners.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools