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Research ArticleHIV
Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation
- View ORCID ProfileJames W. Austin1,*,
- View ORCID ProfileClarisa M. Buckner1,*,
- View ORCID ProfileLela Kardava1,
- View ORCID ProfileWei Wang1,
- Xiaozhen Zhang1,
- View ORCID ProfileValerie A. Melson1,
- Ryan G. Swanson1,
- Andrew J. Martins2,
- View ORCID ProfileJulian Q. Zhou3,
- Kenneth B. Hoehn4,
- View ORCID ProfileJ. Nicholas Fisk3,
- Yiannis Dimopoulos5,
- View ORCID ProfileAlexander Chassiakos5,
- Sijy O’Dell5,
- View ORCID ProfileMargery G. Smelkinson6,
- Catherine A. Seamon7,
- Richard W. Kwan7,
- View ORCID ProfileMichael C. Sneller1,
- Stefania Pittaluga8,
- View ORCID ProfileNicole A. Doria-Rose5,
- View ORCID ProfileAdrian McDermott5,
- Yuxing Li9,10,
- View ORCID ProfileTae-Wook Chun1,
- View ORCID ProfileSteven H. Kleinstein3,4,
- John S. Tsang2,11,
- View ORCID ProfileConstantinos Petrovas5 and
- View ORCID ProfileSusan Moir1,†
- 1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 2Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
- 4Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
- 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 6Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 7Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
- 8Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
- 9Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
- 10Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
- 11NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- ↵†Corresponding author. Email: smoir{at}niaid.nih.gov
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 27 Nov 2019:
Vol. 11, Issue 520, eaax0904
DOI: 10.1126/scitranslmed.aax0904
Vol. 11, Issue 520, eaax0904
DOI: 10.1126/scitranslmed.aax0904
James W. Austin
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Clarisa M. Buckner
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lela Kardava
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wei Wang
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Xiaozhen Zhang
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Valerie A. Melson
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ryan G. Swanson
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Andrew J. Martins
2Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Julian Q. Zhou
3Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
Kenneth B. Hoehn
4Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
J. Nicholas Fisk
3Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
Yiannis Dimopoulos
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alexander Chassiakos
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sijy O’Dell
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Margery G. Smelkinson
6Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Catherine A. Seamon
7Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Richard W. Kwan
7Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Michael C. Sneller
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Stefania Pittaluga
8Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
Nicole A. Doria-Rose
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Adrian McDermott
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yuxing Li
9Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
10Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Tae-Wook Chun
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Steven H. Kleinstein
3Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
4Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
John S. Tsang
2Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
11NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Constantinos Petrovas
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Susan Moir
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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