Research ArticleHIV

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

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Science Translational Medicine  27 Nov 2019:
Vol. 11, Issue 520, eaax0904
DOI: 10.1126/scitranslmed.aax0904

Article Information

vol. 11 no. 520

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 20, 2019
  • Accepted for publication October 2, 2019
  • .

Author Information

  1. James W. Austin1,*,
  2. Clarisa M. Buckner1,*,
  3. Lela Kardava1,
  4. Wei Wang1,
  5. Xiaozhen Zhang1,
  6. Valerie A. Melson1,
  7. Ryan G. Swanson1,
  8. Andrew J. Martins2,
  9. Julian Q. Zhou3,
  10. Kenneth B. Hoehn4,
  11. J. Nicholas Fisk3,
  12. Yiannis Dimopoulos5,
  13. Alexander Chassiakos5,
  14. Sijy O’Dell5,
  15. Margery G. Smelkinson6,
  16. Catherine A. Seamon7,
  17. Richard W. Kwan7,
  18. Michael C. Sneller1,
  19. Stefania Pittaluga8,
  20. Nicole A. Doria-Rose5,
  21. Adrian McDermott5,
  22. Yuxing Li9,10,
  23. Tae-Wook Chun1,
  24. Steven H. Kleinstein3,4,
  25. John S. Tsang2,11,
  26. Constantinos Petrovas5 and
  27. Susan Moir1,
  1. 1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
  4. 4Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
  5. 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  6. 6Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  7. 7Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
  8. 8Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
  9. 9Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
  10. 10Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  11. 11NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  1. Corresponding author. Email: smoir{at}niaid.nih.gov
  • * These authors contributed equally to this work.

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Nov 20191626197128
Dec 20192642276261
Jan 20209236042

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